The underdiagnosis of alpha-1 antitrypsin (AAT) deficiency (AATD) has been recognized for many years, yet little progress has been made in treatment of chainsaw file the disease.In this review, we summarize the AATD disease process as well as its diagnosis and treatment by AAT augmentation therapy.AATD is a rare autosomal disease that primarily aff
Water-induced softening behavior of clay-rich sandstone in Lanzhou Water Supply Project, China
The strength of clay-rich sandstone decreases significantly when in contact with water due to softening effects.This scenario can pose a severe threat to the stability of water diversion tunnels during construction and operation periods.To address the issues related to water-induced softening in clay-rich sandstone zones in a water diversion tunnel
Exploiting graph kernels for high performance biomedical relation extraction
Abstract Background Relation extraction from biomedical publications is an important task in the area of semantic mining of text.Kernel methods for supervised relation extraction are often preferred over manual feature engineering methods, when classifying highly ordered structures such as trees and graphs obtained from syntactic parsing of a sente
Characteristics of Jerk Response Spectra for Elastic and Inelastic Systems
Jerk is the time rate of acceleration and mainly represents the nonstationary component in high frequency band of the earthquake wave.The study on jerk and its response spectra can enhance the recognition of the nonstationary ground motion.The mechanical meaning and research value of jerk are described.Jerk is recommended to be solved by establishi
Real-life challenge: training program on drug use and adolescence in primary health care
ABSTRACT Guidelines emphasize the importance of approaching substance use by adolescents, particularly in primary health care.However, there are problems with its incorporation.The objective of this study was to present the tenga flip orb training stages on the theme for professionals in primary health care.Researchers conducted logistic structurin